Diabetes mellitus,

as manifestation of pathocomplex process

In Greek, the word diabetes literally means "pouring of liquid" (implying excessive diuresis in patients with diabetes mellitus). This term has been used since ancient times until, in 1776, the English Dr. Dobson first identified its sweetness by tasting the urine of diabetic patients. From that time on, the term diabetes was appended with "sweet" or "sugary", giving rise to diabetes mellitus. However, documentary, sugar’s presence in the urine was proven only in 1841.

Once insulin was first used for treating diabetic patients in 1922, it appeared for a while as if the problem of diabetes mellitus was solved once and for all. But only in the sixties of the past century, on the basis of the achieved experiences from treatment of patients suffering from diabetes mellitus, physicians realized that insulin therapy not only failed to eliminate this disease, but also is even not capable to preclude the emergence of such complications of diabetes, as angiopathy, nephropathy, cardiomyopathy, encephalopathy, retinopathy, and prevent the occurrences of hypertension, strokes, and heart attacks.

Today, with the development of science, it is possible to conclude that the problem of diabetes mellitus and its complications is not limited to sugar and insulin alone. This problem has much broader limits.

According to official statistics, diabetes mellitus is ranked third in morbidity and mortality, immediately following cardiovascular and cancer pathologies. However, diabetes mellitus cannot be examined apart from its complications, especially the coronary heart disease, hypertension, as well as strokes and heart attacks.  Hence, it will be more accurate to rank it first along with the diseases of the cardiovascular system.

The incidence of diabetes mellitus is rapidly increasing. In 1965, only 30 million of the global population suffered from diabetes. Seven years later, in 1972, their quantity increased to 70 million and now it reaches 180 million people.

By forming a diagram based on statistical data, it becomes apparent that the initial point of this diagram and hence, the onset of diabetes mellitus as a new nosological entity cannot be too distant.  This means that as its accompanying coronary heart disease and hypertension, diabetes is a disease that came about together with the evolution of modern humanity.

Sugar's etiological role

One of the primary symptoms of diabetes mellitus is increased diuresis accompanied by general weakness, dry mouth (xerostomia) and thirst (polydipsia). These symptoms, along with the appearance of sugar in the urine of diabetic patients were discovered in the 1940s. The detection of urine sugar by tasting and later, laboratory confirmation of this fact with the advent of diagnostic possibilities, provoked scientists to make yet another mistake originating from naive, non-analytical conclusions deduced from direct observations. Thus, the same mistake that was introduced in cardiovascular pathologies in relation to cholesterol and triglycerides and in rheumatic diseases in relation to the streptococci was repeated once again. The sugar that was found in the urine tests of patients suffering from diabetes was ultimately blamed for the onset of diabetes mellitus and its complications. As a consequence, all treatment efforts were directed at reducing the blood sugar level. Beginning from 1920s and till present days, various types of insulin and sugar-reducing pills are being widely applied for this purpose. Nonetheless, no one in the world can show a single individual whose diabetes mellitus and especially its complications would have been eliminated by taking sugar-reducing drugs.

In reality, diabetes is pathocomplex disease. What distinguishes diabetes mellitus from other diseases of pathocomplex origin is that in diabetes, the pancreas involves in the pathological process as a major participant of an cumulative compensatory mechanism capable of excreting pathocomplexes. A radical mode of fighting with pathological immune complexes consists in their disbandment under the influence of factors that must be constantly present in the blood plasma. In the absence of this physiological mechanism, only one emergency mode of excreting pathocomplexes from the body remains. It requires enhanced diuresis, which is achieved through the participation of pancreas, insulin and glucose. For this purpose, on the one hand, the synthesis of insulin in the pancreas is compensatory inhibited by special mechanisms and, on the other, the synthesized insulin itself becomes deprived of sufficient enzyme activity. As a consequence, blood glucose levels rise, and thus, achieving the main of goal of polyuria and hereby, the final task of excreting pathocomplexes from the organism. One of the insulin blocking mechanisms that occur in the blood of patients with pathocomplex-induced diabetes mellitus is the synthesis of antibodies against this substance, that are detected via laboratory blood tests in almost every patient suffering from diabetes. In the course of development of pathocomplex process, pancreas itself and islets of Langerhans are also exposed to attacks by patokomplexes, resulting in subsequent lesions and fibrosis of its highly specialized tissue. Unfortunately, pancreatic dysfunction induced by degenerative changes of its tissue from direct attacks pathocomplexes can be continued in the form of insulin deficiency manifestations and symptoms of diabetes mellitus even after complete elimination of the pathocomplex process, but this time, without explicitly expressed complications.

In many patients, despite the absence of anatomical defects and physiological disorders, blood sugar level at the same time exceeds the norm. In fact, there is nothing illogical or strange in this seemingly at first glance contradictory phenomenon. The quantity of pathological immune complexes in the blood of the people suffering from pathocomplex process sharply increases and they extensively sediment on various organs, including blood vessels, heart, pancreas, kidney, retina, and others. For this reason, in search of compensatory mechanisms, the human organism increases blood sugar levels, thereby triggering intense thirst, polydipsia, and consequently, increased diuresis so that large intake of water and induced excessive urination would wash out the accumulated pathocomplexes.

Several arguments can support the fact that sugar itself does not play an etiological role in the emergence of diabetes:

1. Neither diabetes nor, especially, its complications are cured through the use of insulin injections and per oral sugar-reducing drugs. Thinking logically there should be an established principle, widely adapted in the medical practice, indicating that the disease itself must be completely eradicated by eliminating its etiological factor.

2. Regardless of whether patients with diabetes take medicine to lower their blood sugar levels or not, the complications of this disease such as angiopathy, retinopathy, nephropathy, cardiomyopathy, trophic sores, and others still develop and progress. Moreover, they tend to manifest faster and more intensively in those patients who try to maintain a low blood sugar level by injecting large doses of insulin, thus reducing their own diuresis and hence, excretion of the pathocomplexes that settle unto different organs and trigger the development of diabetes complications. Conversely, patients who inject a threshold and a subthreshold dose of insulin, thereby supporting compensational hyperglycemia and maintaining intensive diuresis contributing excretion of the pathocomplexes, have less pronounced diabetes complications.

3. Diabetes complications in patients who received treatment aimed at eliminating the source of the disease had considerably and in most cases, completely disappeared. Thus, after the elimination of the pathocomplex process, blood sugar levels and the need for compensatory polydipsia and polyuria mechanisms for excreting pathocomplexes reduces. In some patients, who recently started taking insulin, we were even able to achieve its replacement with a minimal dose of oral antidiabetic drugs and sometimes, even its complete abolition, as well as pancreas restoration and blood sugar level normalization.

Statistical data obtained from the treatment results of our method as well as a set of other arguments, including aforementioned, prove once again that diabetes mellitus is a form of pathocomplex process manifestations, when the body tries to excrete pathocomplexes as the primary damaging factors, via one of its defense mechanisms, in this case, hyperglycemia and subsequent polydipsia and polyuria.

It should be noted that there is a perception among endocrinologists of current medicine that the only prescription for children with diabetes should be insulin because allegedly there is no other "effective" alternative to applying oral sugar-reducing drugs for them. Unfortunately, in such cases, this category of "specialists with a capital S" lacks any logic in justifying such prescriptions other than the globally accepted standard phrase that "this is the norm".

From our point of view, confirmed by many years of practice, prescription of insulin to children is advisable only during early stages of the disease when blood sugar levels are sharply increasing and for temporarily reducing them only. Long-term insulin therapy in children is a big and irreversible mistake, and even a crime. This can be verified by living examples of cases when children were led to the state of decompensation within a few years of insulin injections. Our pancreas develops at least until the age of 20 along with the growth of the body, gradually reaching its mature sizes. If diabetes patients are treated with insulin since their early childhood, then the growth of pancreas is almost completely impeded. This occurs because its function is assumed by the exogenous insulin and while remaining inactive, the gland itself begins to dystrophy, delaying further development or even completely atrophying down to pancreatic sclerosis. Consequently, the pancreas starts to lag behind in growth and fixates within an organ according to dimensions typical of the age when diabetes mellitus first occurred. As a result, such individual is completely deprived of his gland post his growth period, i.e. early years of his young hood, and even if the gland did exist, it is so small and inactive that it fails to meet the requirement of his mature organism. This means that such individual will have to depend upon exogenous insulin injections for his short lifetime. Most children with such experiences already suffer from the most severe diabetes complications at a young age, including blindness and renal insufficiency that sooner or later lead to lethal outcomes.

It is important to at least question any method that has reached a dead-end, no matter who is its author, even if it came from the Pope, even if no other alternatives existed at the moment. Exactly this initial questioning is what sparks the study and research in a different direction that sooner or later leads to new scientific theories and methods giving though patients at least some type of hope for a way out of this deadlock. It would be possible to save thousands of sick children from complications of the use of insulin if medical science approached the problem from a different outlook. Complications of diabetes mellitus are much easier to offset in children than in adults because a young body stands a better chance for recovery.

Diabetes classification

Some "intellectual" medical professionals explain insulin prescription with the existence of two types of diabetes mellitus: type 1 and type 2. The classification of diabetes into different types merely based on the kinds of drugs prescribed for its treatment, fails to withstand either logical or scientific criticism. If the doctor prescribed patient with insulin, then it means that he have diabetes mellitus type 1 (insulin-dependent!!!), but if the patient was prescribed with something other than insulin, then it means that he have diabetes mellitus type 2 (non-insulin-dependent!!!). This is merely a game with the forms, where there is no possibility of thinking about the essence and content of the phenomenon itself. To define the sex of just hatched chicken, there is a similar method too. It is enough to throw it upwards. If "SHE" falls down, means that it is a girl and if "HE" – it is a boy!!!

What is interpreted as diabetes mellitus type 1 and type 2 simply reflects different consecutive stages of development transformation metamorphosis of the same disease. Initially, while the pancreas is still capable of synthesizing some of the required insulin, the patients can compensate for its deficit with antidiabetic pills. When just the pancreas completely stops its functioning and is no longer capable of synthesizing its own hormone, the patient is then forced to take the exogenous insulin. These are two gradually transitioning stages of the same pathological process.

Such ubiquitous classifications in medicine never pursued the humane goal of helping people, saving their lives, and finding radical methods of treatment. It would be excellent, if everything would happily end just with acquisition of MD as the prefix to the name of an ordinary individual making him not just an ordinary individual, but a person with a capital P. Yet, on the example of diabetes mellitus, we can see the price of attaining the title of medical science candidates and the disastrous consequences such empty classifications can lead to.

Diabetes mellitus should indeed be subdivided into two types, but not on the basis of the types of drugs prescribed for its treatment, but on the basis of the origin of occurrence of the disease.

The first type can be categorized as diabetes of pathocomplex origin, in which the pancreas is completely healthy and capable of synthesizing sufficient amounts of insulin and the rise of blood sugar levels, polydipsia, and polyuria are defensive compensatory reactions of the organism for the removing the  primary damaging factors pathocomplexes. As it was already noted, this occurs by the synthesis of blocking antibodies against autologous insulin. Gradually, as the disease progresses, in addition to adsorbing on other tissue and systems, the pathocomplexes sediment onto pancreatic tissues, thus inducing its secondary damage and triggering consequences in the form of irreversible pancreatic dysfunction. This process occurs particularly intensively in those patients who resort to active measures for reducing their blood sugar levels, considering it as the etiological factor of diabetes.

The second type of diabetes occurs as a result of any direct damage to the pancreas such as pancreatitis of viral or bacterial origin, or blockage of the pancreatic excretory ducts leading to subsequent necrosis of the pancreatic cells, including under the influence of autologous enzymes that in turn leads to insulin deficiency. Such blockage can be triggered by duodenum’s mucous membrane inflammations as well as helminthiasis and especially ascariasis.

Complications of diabetes mellitus

It is possible to classify all complications of diabetes mellitus by two variations of the pathocomplex process manifestation:

1. Complications that arise as a result of pathocomplex sedimentation on various organs leading to their anatomical damage as well as on blood vessels of various organs, leading to their occlusion, and subsequent cells necrosis and fibrous tissue development in the field of their blood supply.

2. Complications that arise as a result of immune deficiency caused by the pathocomplex process.

An immune deficiency of varying degrees arises in all patients who are affected by the pathocomplex process due to trapping of the B-lymphocytes in the pathocomplex networks. In systemic pathologies, immunodefiency promotes the incidence of upper respiratory tract inflammations, most commonly manifested as angina. In diabetes mellitus, against the background of immune deficiency can develop pyoderma, pyelonephritis, and in advanced stages, even tuberculosis of the lungs.

Due to narrowing and clogging of blood vessels throughout the body, complications associated with reduced organ blood supply are the first to manifest. Restoration of blood circulation to the lower limbs, as to any other organs affected by diabetes mellitus is the only possible way of healing trophic ulcers and recovering the given organ’s functions. Trophic ulcers are illustrative examples that verify that there is no other way to eliminate the complications of diabetes. None of the local-effect drugs used to treat trophic ulcers are capable of definitively eliminating them without a hemodynamic compensation.

The complications of diabetes mellitus can also be reflected in the form of cardiac vasoconstriction with subsequent development of coronary heart disease that often leads to myocardial infarctions. Diabetic angiopathy is often the cause of thrombotic and especially, hemorrhagic strokes.

One of the most dangerous complications of diabetes of pathocomplex origin is kidney damage (nephropathy). Intensive excretion of pathocomplexes via kidneys, which is the body’s defensive action, triggers serious damage to their glomerular apparatus down to occurrence of renal insufficiency with ensuing complications following from it.

Retinal damage (retinopathy) that gradually leads to blindness is also one of the worst complications of diabetes mellitus.

Practice along with scientific analysis based on the theory of the pathocomplex process proves that the more sugar-reducing drugs, especially insulin, patients consume during the period of illness, the earlier and the more intensively are manifested the complications of diabetes. The reason, as already mentioned, lies in the fact that artificial normalization of blood sugar levels reduces diuresis, as body’s defensive reaction for removing pathocomplexes. Therefore, due to artificially reduced diuresis, the accumulated pathocomplexes widely adsorb onto various organs, especially kidneys, heart and eye retina, damaging them thereby.

Treatment of diabetes mellitus

All treatment methods of diabetes mellitus applied in the current medicine are not directed at eliminating the source and the cause of the disease, but merely limited to lowering blood sugar levels and removing the symptoms of hyperglycemia. However, the use of insulin and oral antidiabetic drugs is actually a fight with body’s natural defense mechanisms. Therefore, reducing high blood sugar measures should be limited just to lowering it to the allowable threshold level of body-tolerated hyperglycemia and never to a state of iso- or hypoglycemia in any way. Neither in diabetes mellitus nor in any other disease can sugar itself be a damaging factor to human body. Glucose has always been a major source of energy for all living beings and therefore, it cannot suddenly become a foreign and moreover, pathogenic agent to them. The main causes of diabetes mellitus and its complications in the forms of various tissue and blood vessel damages are the pathological immune complexes (pathocomplexes) which quantity sharply increases in the blood, including for this disease. In diabetes, blood sugar levels rise for the sole purpose of stimulating diuresis, by which the human body tries to wash out pathocomplexes as the true damaging factors along with the urine output through a compensatory defensive mechanism. Therefore, all measures aimed solely on struggle against sugar in diabetes, eliminate the physiological compensatory defensive mechanisms initiated by the body itself for controlling the pathocomplex process. This fact is proved by the example of experiences of millions people suffering from diabetes. As long as the patients use oral drugs for reducing blood glucose levels, the complications of diabetes mellitus are not expressed as severe. Throughout the long years of presence of diabetes mellitus they rarely notice its complications. However, as soon as they start insulin therapy, they become subjected to a sharp acceleration of development of renal insufficiency, angiopathy, retinopathy, cardiomyopathy and other complications of diabetes mellitus.

Thus, an effective treatment of diabetes mellitus cannot be limited to merely treating its symptoms in any way, and must be exactly directed also on the elimination of the root of the disease, i.e. the pathocomplex process. With elimination of the pathocomplex process in the early stages in the patient’s organism all complications of diabetes such as angiopathy, retinopathy, cardiomyopathy, encephalopathy, and others, as well as immune deficiency and all the associated complications can be maximally eliminated, depending on the condition of the individual patient, and to the extent these damaged organs can be recovered. (рис. 0014) Naturally, the degenerative changes emanating from long-term application of insulin and the corresponding dysfunctions of various organs cannot be fully recovered even with our method of treatment. This is due to the fact that highly specialized tissues of the damaged organs are replaced by fibrous tissues that cannot be regenerated back to correspondingly functioning tissues. For this reason, the earlier the treatment of diabetes mellitus based on the theory of the pathocomplex process will be performed, the better are the results of damaged organs regeneration that can be achieved.

Blood sugar level of patients suffering from diabetes depends on the degree of damage inflicted to the specialized tissues of the islets of Langerhans over the years of the illness to realistically assess and predict the possibility of their restoring for synthesis of sufficient amounts of insulin.

Thus, the presence of pathocomplexes in the blood circulation, on the one hand, and the substitutive insulin therapy adopted in the current medicine, on the other hand, lead to irreversible anatomic damage of the pancreas that makes a patient permanently dependent upon the exogenous hormone. Therefore, in line with all aforementioned reasons, blood sugar levels in advanced stages of diabetes are rarely reduced even after our method of treatment aimed at eliminating the source of this illness, i.e. the pathocomplex process. However, the major complications of diabetes mellitus, as it was already mentioned, are eliminated to the extent of the body’s capacity.

How can one prevent diabetes mellitus?

No one is immune from the first type of diabetes mellitus of pathocomplex origin. This is the fate of the 20th and 21th century’s mankind. The pathocomplex process is present in 80% of global middle-aged population. As for preventing the second type of diabetes mellitus that results from damage to the pancreas, it is important to undertake all prevention measures against development of pancreatitis and duodenitis. For this purpose, it is necessary to exclude all factors that contribute to the formation of erosions and ulcers in duodenum’s mucous membrane. One of the reasons of excessive and untimely secretions of the pancreas and duodenal mucosa that in turn provoke the formation of ulcers is stress. To prevent the clogging of pancreatic and biliary ducts by helminthes, it is recommended to take anthelminthic drugs every six months. This measure effectively prevents the onset of diabetes mellitus and the formation of gallstones in the gallbladder, especially in children.

One of the most important conditions for the development of endocrine organs in children consists in eating those food products that the specific organs are intended to digest. In case of insufficient intake of food products designed for physiological functioning of certain organ during the period of its growth the anatomical and physiological development of this organ in consequence are retarded. The pancreas is designed for the digestion of proteins and sugar. Therefore, if during the pancreatic growth in childhood, limit the amount of sweet and protein foods, this gland will fail to develop sufficiently, increasing chances of the pancreas malfunction in the form of diabetes mellitus in future. Thus, contrary to socially accepted unscientific ideas, children should be provided with sufficient amounts of sweet and protein foods for the pancreatic islets of Langerhans to develop under the influence of the natural incentive for mature functioning in the future. This seemingly contradictory factor is one of the major preventive measures against diabetes mellitus in adulthood.

Finally, since skeptics find it convenient to brand any new scientific discovery as "folk medicine" to refute it without going to further troubles, we want to emphasize that the theory of the pathocomplex process and the treatment method derived from it have no relation to traditional medicine in any of its forms whatsoever and while they are significantly different from the treatment methods adapted in the current medicine, and are implemented solely within the scope of modern medicamentous medicine and all drugs administered are on the pharmacological market for over 40 years and are registered with heath ministries of virtually all countries around the world.

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